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This 2nd edition has been fully updated and gives an overview about the broad group of inborn errors of metabolism, thereby helping colleagues working in hospitals as well as in private practices. Beside newborn screening, the most important biochemical and clinical key symptoms and differential diagnoses are presented. In addition, the most frequent inborn errors of metabolism are illustrated in short and well arranged form. Special attention is given to tables, flow charts for differential diagnosis, special metabolic investigations as well as treatment and emergency management. In addition, original figures from illustrative clinical or radiological findings as well as hints to updated internet links are integrated. Mehr erfahren

The treatment of coronary artery disease (CAD) encompasses many strategies all of which aim to improve symptoms and prognosis. While in the acute coronary syndrome, early revascularisation (usually by means of PCI and stent implantation) is the urgent goal of treatment, drug therapy initially has only a supportive role here but is also important for improving prognosis. The situation is reversed in the case of the treatment of chronic stable CAD: here conservative drug therapy has the dominant role and if implemented optimally is so successful that the prognosis cannot be further improved with additional PCI and stent implantation. Therefore, the indication for revascularisation should not only be based on an angiographic but also on a functional (FFR, fractional flow reserve) assessment of the stenosis. This book is therefore a critical presentation of the benefit of treatment strategies in the different forms of CAD. In addition to the value of lifestyle changes, it deals with the evaluation of the various drug therapies, invasive procedures such as PCI and stent implantation, bypass surgery and electrotherapeutic measures with ICD, CRT and cardiac pacemakers. The authors have succeeded in producing a textbook that is not just of interest to the attending doctor but also for patients affected by the disease. A textbook from the viewpoint: what is optimal? What is economic? What is evidence-based? Mehr erfahren

Heart failure is a syndrome with various aetiologies and a poor prognosis. New pathophysiological findings have led to treatment strategies with improved prognosis. For want of a causal treatment option the focus lies on drug strategies. In addition, surgical or other procedures come into consideration. All these treatment strategies are presented in detail, analysed and evaluated with reference to the pathophysiology and study data. An assessment is also made regarding the European (ESC) and US guidelines (ACC/AHA) on completion of each chapter topic. This emphasises the level of evidence for each recommended therapy. Such recommendations are important because a guideline-oriented treatment strategy improves the prognosis in heart failure! The authors have approached this sophisticated subject in a structured, vivid and richly illustrated form, where even the latest study data are taken into account. Thus, this book is a highly topical and practical treatment guideline for doctors practicing Cardiology. Mehr erfahren

Understanding the pathophysiology of Eustachian tube dysfunction is critical for the management of ear disease. The complex anatomy of the Eustachian tube through the base of the skull makes its function difficult to assess and many early attempts of surgical treatment were unsuccessful. This book discusses anatomy, physiology, pathology, diagnosis and the evolution of surgery of the Eustachian tube. It encapsulates our present knowledge of the principles and present day practice of the management of Eustachian tube dysfunction. Mehr erfahren

Understanding the pathophysiology of Eustachian tube dysfunction is critical for the management of ear disease. The complex anatomy of the Eustachian tube through the base of the skull makes its function difficult to assess and many early attempts of surgical treatment were unsuccessful. This book discusses anatomy, physiology, pathology, diagnosis and the evolution of surgery of the Eustachian tube. It encapsulates our present knowledge of the principles and present day practice of the management of Eustachian tube dysfunction. Mehr erfahren

Applications of heat have attractive potentials in oncology. Serious assessment is sometimes difficult, because thermotherapy or hyperthermia emerge today in various forms and labels such as nanotherapy, radiofrequency hyperthermia, annular phased array system, MR thermo-graphy, capacitive heating, whole body hyperthermia etc. The book provides an overview on the current status of thermotherapy and directions of further research and is directed to newcomers, but contains as well valuable hints and suggestions for specialists. A central concern is to identify promising indications for hyperthermia based on clinical studies and embedded into actual oncological guidelines. Another focus is a detailed description of heating technology in order to convey an idea whether or not a target is heatable and how to apply available devices at best. The author of this book is a renowned protagonist in this field and provides an essence useful for physicians as well as physicists, engineers and other scientists interested in the field of thermotherapy. Mehr erfahren

Intraoperative radiotherapy (IORT), as a method in the subspecialty of interventional radiation oncology, is one of the most dynamically growing fields in oncology. During the last decade, the number of centers offering IORT to patients has rapidly increased. There are more than 300 active IORT centers worldwide. This interest has mainly been stimulated by the clinical benefits of IORT in breast cancer. The 2nd edition of this handbook includes the basics of the IORT principles, a detailed description of techniques for IORT and a review of ongoing trials showing the benefits of this method in the treatment of breast cancer. Mehr erfahren

Anaemia and iron deficiency are among the top causes of morbidity and mortality throughout the world. While countries with chronic malnutrition have a high prevalence of people with iron-deficiency anaemia, iron deficiency states without anaemia are frequently found in countries with normal nutrition. Successful iron therapy depends on the correct diagnosis as well as the choice of effective iron preparations. This book deals with the diagnosis and treatment of iron deficiency states in females and presents numerous obstetric and gynaecological case reports encountered in daily practice. Mehr erfahren