Clinical Use of Immunoglobulins

Immunoglobulins derived from human plasma are widely used for replacement and immunomodulation. Some applications are generally accepted as "indications". Others, especially in rare diseases, are still a matter of debate. In this volume, therapy with immunoglobulin is introduced and the data underlying the clinical uses of immunoglobulins reviewed. A superb international collection of authors with diverse expertise have put forth a tremendous effort to identify key messages as well as existing controversies. This edition should facilitate the understanding of immunoglobulin therapy and help clinicians provide immunoglobulins rationally to best exploit their potential in treatment of disease.Table of contents:1. The Biology of Antibody Synthesis2. Pathogen Safety of Immunoglobulin Preparations3. Passive Immunoprophylaxis with Immunoglobulins4. Sepsis in Neonates: Prevention and Adjuvant Therapy with Intravenous Immunoglobulin5. Application of Immunoglobulins in Other Infections6. Use of Immunoglobulins in Congenital and Acquired Immunodeficiencies7. IVIG Treatment of Secondary Immune Deficiencies in Adults8. Immunomodulation with Immunoglobulins: Mechanisms9. Use of immunoglobulins in Hematological Cytopenias10. Further Applications of Immunoglobulin Therapy in Pediatric Hematology/Oncology11. Use of Immunoglobulins in Rheumatologic Disorders and Systemic Autoimmunopathies12. Use of Immunoglobulins for Kawasaki Disease and other Vasculitic Diseases13. The Use of Immunoglobulins for Neurological Diseases in Children and Adults14. Use of Intravenous Gammaglobulin (IVIG) in Kidney Transplantation15. Use of Immunoglobulins in Allergic Diseases16. Further Indications for Intravenous Immunoglobulins17. Intravenous Immunoglobulin in the Prevention of Recurrent Miscarriage